An organisation I belong to accidentally sent an email 'to' about a third of its membership. There were between 1500 and 2000 addresses in the to list!
At the time I received this I had the settings to view all of the addresses. More of this below.
I found two issues. First, although all of the to: addresses could be seen, none of the message could. This despite the fact that the first lines of the message do appear in the message list, so were downloaded from the start.
Second, the scrolling action became jerky and stiff. It was not possible to 'flick' up to scroll to the bottom. I had to drag through the whole lot.
Now the good news - tapping in a blank area of the header collapses the list, and makes the content visible. Combined with the fact that this email was truly exceptional, it is clear this is either not a problem, or at least is not significant.
What would be interesting to know, though, is: is this an android effect or an app effect?