Since yesterday I'm getting the same (or similar) problem. I've a few Gmail accounts connected to AquaMail (1.7.1-88) for a few years long and now all complain "SMTP: connection failure, handshake failed". I've tried to check and modify the accounts' settings, but nothing helped. No matter whether using OAUTH2 or not, SSL/STARTTLS, which authentication - IMAP works flawlessly and SMTP does not go through. (I've yet to check Thunderbird on a computer.)
Sent from a touch display, which took care of perfectly scrambling my thoughts.